How could sugar be used to boost cancer treatment?

Sugars are one of the most important molecules found in our body. They are vital for our cells to function and for our organs to keep us alive. Sugar, usually in the form known as glucose, is broken down by cells to release the energy they need to survive. Find out how Worldwide Cancer Research scientist, Professor Kevin Ryan, is using sugar to enhance the effect of cancer treatment.

What is the relationship between sugar and cancer?

Cancer cells churn through sugar molecules at an accelerated rate in order to release the energy they need to grow and divide in a dangerous, erratic way. This “addiction” to glucose is such a defining feature of cancer cells that cancer can be detected through imaging techniques that spot the sugar feeding-frenzy in diseased parts of the body.

But the relationship between sugar and cancer is more complex than you might think.

Firstly, it’s not just cancer cells that need glucose to survive – your healthy cells need it too. And interestingly, there is also evidence appearing that there might also be a link between sugar and cancer treatment.

A point highlighted by research from one of our scientists, Professor Kevin Ryan, who has uncovered a counterintuitive way to disrupt the cancer cells ability to get their energy from glucose – by feeding them another sugar called mannose. We asked Professor Ryan to explain.

Mannose is a naturally occurring sugar that is highly related to glucose and we found that mannose could dramatically repress the growth of certain cancer cell types, but not others.

We found that mannose doesn’t stop glucose getting into tumour cells but interferes with how the glucose is broken down once inside the cell – disrupting how cancer cells generate energy from glucose or use it to manufacture building blocks that the cells use to grow and divide.

Importantly, the research showed that the size of tumours in mice with cancer were significantly decreased when treated with mannose and chemotherapy, either alone or in combination. While either treatment alone was able to reduce tumour size, the effect was enhanced when both treatments were given in combination.

What we need to see now is if there’s feasibility to use mannose in humans with cancer.

We need to know which tumours will respond so we can work out which patients would benefit. So, we need to do more pre-clinical work looking at the effects of mannose on specific cancers before ultimately taking this forward into clinical trials.”

Although we haven’t done the clinical studies yet to know if mannose is therapeutically beneficial to humans, we could envisage in the future that this sugar could be used to counteract the glucose addiction of tumours.

Perhaps with more research we could see mannose given in combination with chemotherapy to somehow boost the effect of standard treatments.

The team’s study also found that mice that had their drinking water supplemented with a high level of mannose seemed to be less likely to develop tumours without having any negative impact on the health of the animals - however, Professor Ryan is quick to dismiss any claim that mannose could ward off cancer in humans.

So far the team have only looked at this effect in cells and in mice and we do not yet know how this will translate to people - the research is still in the relatively early stages right now. There’s a lot more work to do before we can accurately predict when this research could lead to a usable treatment for patients.

But based on current findings, we can certainly see the possibility that in the future we might have a cheap and safe way to slow down cancer growth or even to boost the effects of chemotherapy. That’s why funding bold research like this is so important – because it’s only by understanding more about cancer that we can find new cures in the future.

We cannot fund vital research like this without the support of Curestarters like you. Together we can save lives by discovering the next cure for cancer. Will you join us today?