Complete

Tracking immune cells to improve immunotherapy

Cancer types:

General cancer research

Project period:

Research institute:

University of Birmingham

Award amount:

£170,685

Location:

United Kingdom

David Withers
Researcher Professor David Withers

Professor David Withers and his team are trying to gain a better understanding of how the immune system fights cancer, hoping that the insights from their work will help to design better immunotherapies.

Hope for the future

Using the body’s immune system to fight cancer has shown great promise in the form of immunotherapies. Unfortunately, these treatments tend to only work in a minority of patients and we still do not understand exactly how immunotherapy helps the body’s immune system fight cancer. 

Professor Withers and his team are now trying to find out more about how our immune system and immunotherapies work against cancer. They hope that a better understanding of these processes will help to improve the current immunotherapies, making them useful for more patients. 

Meet the scientist

Professor David Withers likes to spend his time away from the lab with his two children and the family dog. He lives in Malvern, which also offers great opportunities for running and walking. 

The science

Checkpoint inhibitors are a type of immunotherapy that take the brakes off the immune system, allowing it to find and destroy cancer cells that have previously been hiding. While these treatments show great promise, they currently only work on very few patients and we do not yet fully understand how they work. It is not very well understood which immune cells are required for an optimal response and where these cells are located. 

Professor David Withers and his team developed an innovative new way to track the movement of immune cells in and out of tumours and between different tissues in the body. They are now using their new approach to better understand the cells that orchestrate the anti-tumour response and investigate how checkpoint inhibitors work. The team hopes that these insights will help to design better therapies which will benefit a larger number of patients. 

I think everyone’s lives are affected by cancer and it is in the back of many people’s minds as they get older. Knowing that all cancers had good treatment options would be more than enough to dream of I think and a really worthy goal. 

David Withers
Professor David Withers

Related projects

Andres Hidalgo Headshot

Active Spain

Lung cancer

How do cancer cells modify white blood cells to help tumours grow?

Researchers want to help immunotherapy work for more cancer patients by understanding how cancers hijack our immune system and preventing this happening 

Researcher: Dr Andrés Hidalgo

Understanding how cancer cells modify white blood cells to help tumours grow
Andrew Beekman and Team

Active United Kingdom

General cancer research

Can we stop cancer becoming resistant to chemotherapy?

Chemotherapy can sometimes stop working, so this project is hoping to better understand why and find ways to give more, better options to cancer patients.

Researcher: Dr Andrew Beekman

Stopping cancer becoming resistant to chemotherapy
Tim Elliott and Team

Active United Kingdom

General cancer research

Can we predict which patients will respond to immunotherapy?

This project hopes to open up exciting possibilities for personalised cancer treatment by finding how to predict which patients will respond best to treatment.

Researcher: Professor Tim Elliott

Finding ways to predict which patients will respond to immunotherapy
Share this page