What’s the risk? Predicting endometrial cancer using genetics and measures of obesity
Co-funded with:
Cancer Australia
Cancer types:
Endometrial cancer
Project period:
–
Research institute:
QIMR Berghofer Medical Research Institute
Award amount:
£179,046
Location:
Australia
Dr Tracy O’Mara and her team are trying to understand how obesity increases the risk of developing endometrial cancer. They hope to create a risk scoring system for endometrial cancer and explore how helping reduce risk factors like obesity could have an effect.
Hope for the future
Endometrial cancer is usually diagnosed early and treated successfully, however cases have been increasing in many western countries. This may be because age and obesity are the most important risk factors for endometrial cancer, and many of these countries have an aging population and growing obesity problem. However, we don’t currently understand exactly how obesity increases the risk of developing endometrial cancer.
Meet the scientist
Dr Tracy O’Mara enjoyed learning about chemistry and physics in high school, but it took a brief step away from science at university to help her realise that life sciences were the right path for her. Dr O’Mara is also a busy mum of four! In her free time, she enjoys movies, good food, art, books, and theatre.
The science
Endometrial cancer is often caught early and can be successfully treated, however some treatments can have life-long effects on health and fertility. If we could identify people who are more risk of developing endometrial cancer, targeting preventative treatments for risk factors such as obesity in those patients could be an effective way to prevent many cases of endometrial cancer.
Dr Tracy O’Mara and her team are developing a new way to predict which patients are at a higher risk of developing endometrial cancer. The researchers are currently running the world’s largest genetic study of endometrial cancer and have found several genetic risk factors for endometrial cancer. They are now combining this information with measures of other obesity-related risks, such as BMI and waist-hip ratio, to look for links between obesity and endometrial cancer and use this to predict the risk of developing endometrial cancer.
The researchers also hope to predict the benefits of personalised preventative treatments, such as weight loss surgery, and see how much treatments like these could benefit patients with a high genetic risk for endometrial cancer. In the future, Dr O’Mara and her team hope that they will uncover new knowledge about how obesity increases the risk of endometrial cancer, and that their new risk scoring system could help find people at high risk to prevent the disease ever developing.
This project is 50% co-funded with Cancer Australia.
There is so much amazing research with incredible potential that would not happen without funding from people like you. You’re making a real difference and we really appreciate everything you have done.
Active Spain
Lung cancer
This project hopes to find a way for immunotherapies to work better, for more cancer patients. Using cutting-edge technologies they will test out a potential new way to treat cancer and explore how to advance it towards the clinic.
Researcher: Dr Alfonso Calvo
Can we stop cancers hiding from immunotherapy?
Active USA
Breast cancer
This project hopes to develop a new way to identify and target prostate and breast cancer cells in the body using tiny molecular ‘flags’, called minibodies.
Researcher: Dr Tanya Stoyanova
Mini but mighty: Using ‘minibodies’ to detect and treat breast and prostate cancer
Active United Kingdom
Prostate cancer
This project aims to find vital new treatments for advanced prostate cancer that stops responding to other treatments or comes back after treatment.
Researcher: Dr Claire Fletcher
Developing a brand-new treatment for advanced prostate cancer